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What is progesterone deficiency?

In a healthy menstrual cycle, estrogen and progesterone work in a balanced manner. The first half of the cycle is characterized by estrogen dominance, promoting the growth and development of the uterine lining. After ovulation, progesterone becomes dominant, preparing the uterus for a potential pregnancy and counteracting some of the effects of estrogen.


The menstrual cycle, in essence, resembles a pregnancy-like state during the luteal phase, where progesterone is dominant. If an embryo implants, the hormonal processes initiated at ovulation continue to support pregnancy until childbirth. If there is no implantation, progesterone dominance is terminated, allowing estrogen to enter tissues and triggering menstruation.


When there is a lack of robust progesterone production, estrogen dominance persists, which can lead to symptoms like premenstrual syndrome (PMS). If this hormonal imbalance is not corrected during pregnancy by the placenta’s significant production of progesterone, it can contribute to conditions such as preeclampsia, toxemia of pregnancy, eclampsia, and postpartum depression. In addition, during perimenopause and menopause, progesterone production tends to naturally decline, causing a cascade of issues.


In summary, progesterone deficiency disrupts the natural hormonal balance in the menstrual cycle, leading to estrogen dominance and various associated symptoms.+


  1. Period irregularities

Progesterone is responsible for maintaining the second half of the menstrual cycle, known as the luteal phase. A deficiency in progesterone can lead to inadequate preparation of the uterine lining, resulting in irregularities in the menstrual cycle. This may include missed periods, unusually short or long cycles, or irregular bleeding.

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2. High Cortisol

In the presence of progesterone deficiency, there is an overproduction of cortisone, a stress hormone. Elevated cortisone levels contribute to several adverse effects on the body, including osteoporosis, accelerated aging of the skin, impairment of brain cells, and the accumulation of adipose tissue, particularly in the back and abdominal regions. This intricate hormonal imbalance underscores the interconnected nature of reproductive and stress-related hormones, emphasizing the importance of maintaining a delicate equilibrium for overall health.

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3. Fibrocystic breasts

Progesterone plays a role in balancing the effects of estrogen on breast tissue. A deficiency in progesterone relative to estrogen can result in increased breast tissue sensitivity, leading to the development of fibrocystic breasts. This condition is characterized by the formation of lumps and cysts in the breast tissue.

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4. Canker sores

While the exact connection between canker sores and progesterone deficiency is not fully understood, some studies suggest that hormonal fluctuations, including low progesterone levels, may contribute to the development of these painful mouth ulcers. Hormonal imbalances can affect the immune system, potentially making individuals more susceptible to oral infections.


5. Edema

Progesterone helps regulate fluid balance in the body. A deficiency in progesterone can disrupt this balance, leading to fluid retention and the development of edema, which is the swelling caused by excess fluid trapped in body tissues. This fluid retention can manifest as bloating, particularly in the extremities.

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